2. Academic Validation
  3. Alamandine: a new member of the angiotensin family

Alamandine: a new member of the angiotensin family

  • Curr Opin Nephrol Hypertens. 2014 Mar;23(2):130-4. doi: 10.1097/01.mnh.0000441052.44406.92.
Daniel C Villela 1,  Danielle G Passos-Silva,  Robson A S Santos
Affiliations

Affiliation

  • 1 aNational Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais bInstituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Rio Grande do Sul, Brazil.
PMID: 24389733 DOI: 10.1097/01.mnh.0000441052.44406.92
Abstract

Purpose of review: In this article, we review the recent findings regarding a new derivative of angiotensin-(1-7) [Ang-(1-7)], alamandine, and its receptor, the Mas-related G-coupled receptor type D (MrgD) with a special emphasis on its role and how it can be formed.

Recent findings: Over the last decade, there have been significant conceptual changes regarding the understanding of the renin-angiotensin system (Ras). A cardioprotective axis has been elucidated by the discovery of the Mas receptor for the biologically active Ang-(1-7), and the angiotensin-converting Enzyme 2 (ACE2) that coverts Ang II into Ang-(1-7). In addition, several components of the system, such as Ang-(1-12), Angiotensin A (Ang A) and the newly discovered peptide, alamandine, have been identified. Alamandine is generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7).

Summary: Alamandine is a vasoactive peptide with similar protective actions as Ang-(1-7) that acts through the MrgD and may represent another important counter-regulatory mechanism within the Ras.

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