2. Academic Validation
  3. Anti-hepatitis C virus dinorditerpenes from the roots of Flueggea virosa

Anti-hepatitis C virus dinorditerpenes from the roots of Flueggea virosa

  • J Nat Prod. 2014 Jan 24;77(1):22-8. doi: 10.1021/np400528h.
Chih-Hua Chao 1,  Ju-Chien Cheng,  De-Yang Shen,  Tian-Shung Wu
Affiliations

Affiliation

  • 1 School of Pharmacy, China Medical University , Taichung 40402, Taiwan.
PMID: 24400834 DOI: 10.1021/np400528h
Abstract

Along with four known Terpenoids (1-4), eight new dinorditerpenes (5-12) were isolated and identified from the roots of Flueggea virosa. The absolute configurations of 4-6 were determined by the Mosher's method, and that of 5 was confirmed by single-crystal X-ray diffraction analysis. Using the hepatitis C virus Cell Culture infection system, compounds 1, 3, 11, and 12 exhibited significant anti-HCV activity with EC50 values of 5.6, 5.0, 7.5, and 6.6 μM, respectively. Compounds 11 and 12 were nontoxic toward the tested Huh7.5 cell lines.

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