2. Academic Validation
  3. Trichodermone, a spiro-cytochalasan with a tetracyclic nucleus (7/5/6/5) skeleton from the plant endophytic fungus Trichoderma gamsii

Trichodermone, a spiro-cytochalasan with a tetracyclic nucleus (7/5/6/5) skeleton from the plant endophytic fungus Trichoderma gamsii

  • J Nat Prod. 2014 Jan 24;77(1):164-7. doi: 10.1021/np4007487.
Gang Ding 1,  Hailou Wang,  Li Li,  Bo Song,  Hong Chen,  Hongwu Zhang,  Xinzhong Liu,  Zhongmei Zou
Affiliations

Affiliation

  • 1 Institute of Medicinal Plant Development , Beijing, People's Republic of China.
PMID: 24422592 DOI: 10.1021/np4007487
Abstract

Trichodermone (1), the first spiro-cytochalasan with an unprecedented tetracyclic nucleus (7/5/6/5), together with its possible biosynthetic precursor aspochalasin D (2), was isolated from the endophytic fungus Trichoderma gamsii. Compound 2 displayed moderate inhibitory activity against HeLa cells with an IC50 value of 5.72 μM.

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