2. Academic Validation
  3. Antifungal ether diglycosides from Matayba guianensis Aublet

Antifungal ether diglycosides from Matayba guianensis Aublet

  • Bioorg Med Chem Lett. 2014 Mar 1;24(5):1414-6. doi: 10.1016/j.bmcl.2014.01.022.
Polyana A de Assis 1,  Phellipe N E T Theodoro 1,  José E de Paula 2,  Ana J Araújo 3,  Letícia V Costa-Lotufo 3,  Sylvie Michel 4,  Raphaël Grougnet 4,  Marina Kritsanida 5,  Laila S Espindola 6
Affiliations

Affiliations

  • 1 Laboratório de Farmacognosia, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, 70910-900 Brasília, DF, Brazil.
  • 2 Laboratório de Anatomia Vegetal, Universidade de Brasília, Brasília, Brazil.
  • 3 Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, Brazil.
  • 4 Laboratoire de Pharmacognosie, U.M.R./C.N.R.S. 8638, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4 Avenue de l'Observatoire, 75006 Paris, France.
  • 5 Laboratoire de Pharmacognosie, U.M.R./C.N.R.S. 8638, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4 Avenue de l'Observatoire, 75006 Paris, France. Electronic address: marina.kritsanida@parisdescartes.fr.
  • 6 Laboratório de Farmacognosia, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, 70910-900 Brasília, DF, Brazil. Electronic address: darvenne@unb.br.
PMID: 24485783 DOI: 10.1016/j.bmcl.2014.01.022
Abstract

Since the 1960s, Fungal infections have become a major worldwide public health problem. Antifungal treatments have many limitations, such as toxicity and resistance. Matayba guianensis Aublet (Sapindaceae) was chemically investigated as part of our ongoing search for lead molecules against fungi in the Brazilian Cerrado biome. The ethanolic extract of M. guianensis root bark revealed the presence of two previously unreported ether diglycosides: matayoside E (1) and F (2) with anti Candida activity, along with two known compounds: cupanioside (3) and stigmasterol (4).

Keywords

Antifungal activity; Brazilian Cerrado; Ether diglycosides; Matayba guianensis; Matayosides E and F.

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