2. Academic Validation
  3. Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives

Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives

  • Med Chem Res. 2014;23(3):1519-1536. doi: 10.1007/s00044-013-0740-z.
Daniel Szulczyk 1,  Anna Bielenica 1,  Michał A Dobrowolski 2,  Lukasz Dobrzycki 2,  Mariola Krawiecka 1,  Bożena Kuran 1,  Marta Struga 1
Affiliations

Affiliations

  • 1 Department of Medical Chemistry, Faculty of Medicine, Medical University of Warsaw, Oczki 3 Street, 02-007 Warsaw, Poland.
  • 2 Faculty of Chemistry, University of Warsaw, Pasteura 1 Street, 02-093 Warsaw, Poland.
PMID: 24489455 DOI: 10.1007/s00044-013-0740-z
Abstract

A series of arylpiperazine derivatives of 1,16-diphenyl-19-azahexacyclo-[14.5.1.02,15.03,8.09,14.017,21]docosa-2,3,5,7,8,9,11,13,14-nonaene-18,20,22-trione and 4,10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione was synthesized. The pharmacological profile of compound 4 at the 5-HT1A receptor was measured by binding assay. The title compounds were tested in cell-based assay against the human immunodeficiency virus type-1. The X-ray crystallographic studies of derivatives 2, 6, 7, 11, 19, and 20 were presented.

Keywords

5-HT1A receptor; Arylpiperazines; Diels–Alder reaction; X-ray crystallography.

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