2. Academic Validation
  3. Cytotoxic dammarane-type triterpenoids from the stem bark of Dysoxylum binecteriferum

Cytotoxic dammarane-type triterpenoids from the stem bark of Dysoxylum binecteriferum

  • J Nat Prod. 2014 Feb 28;77(2):234-42. doi: 10.1021/np400700g.
Hui-Jiao Yan 1,  Jun-Song Wang,  Ling-Yi Kong
Affiliations

Affiliation

  • 1 State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
PMID: 24547740 DOI: 10.1021/np400700g
Abstract

Fourteen new dammarane-type triterpenoids (1-14) and 11 known analogues were isolated from the stem bark of Dysoxylum binecteriferum. The absolute configurations were established by comparison with the literature or by Mo2(OAc)4-induced electronic circular dichroism data. All isolates were evaluated for their cytotoxicities against three human Cancer cell lines as well as their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. Compounds 4 and 8 displayed moderate cytotoxicities against HepG2 with IC50 values of 6.5 and 8.0 μM, respectively.

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