A review of non-nucleoside anti-hepatitis B virus agents

Eur J Med Chem. 2014 Mar 21:75:267-81. doi: 10.1016/j.ejmech.2014.01.046.

Fan Zhang ¹, Gang Wang ²

Affiliations

1 School of Pharmacy, Liaoning Medical University, No. 40, Section 3, Songpo Road, Linghe District, Jinzhou 121001, PR China. Electronic address: zhangfan830720@163.com.
2 School of Pharmacy, Liaoning Medical University, No. 40, Section 3, Songpo Road, Linghe District, Jinzhou 121001, PR China.

PMID: 24549242 DOI: 10.1016/j.ejmech.2014.01.046

Abstract

Hepatitis B Virus is the most common cause of chronic liver disease worldwide. Currently approved agents of chronic HBV Infection treatment include interferon and nucleoside analogues. However, the side effects of interferon and the viral resistance of nucleoside analogues make the current treatment far from satisfactory. Therefore, new drugs with novel structures and mechanisms are needed. Recently, a number of non-nucleoside HBV inhibitors have been obtained from natural sources or prepared by synthesis/semi-synthesis. Some of them exhibited potent anti-HBV activity with novel mechanisms. These compounds provide useful information for the medicinal chemist to develop novel non-nucleoside compounds as anti-HBV agents.

Keywords

Hepatitis B virus; Inhibitor; Natural products; Non-nucleoside; Small-molecule inhibitors; Synthetic compounds.

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