2. Academic Validation
  3. Synthesis and antiproliferative evaluation of 13-aryl-13H-benzo[g]benzothiazolo [2,3-b]quinazoline-5,14-diones

Synthesis and antiproliferative evaluation of 13-aryl-13H-benzo[g]benzothiazolo [2,3-b]quinazoline-5,14-diones

  • Bioorg Med Chem Lett. 2014 Mar 15;24(6):1462-5. doi: 10.1016/j.bmcl.2014.02.018.
Liqiang Wu 1,  Chong Zhang 2,  Weilin Li 2
Affiliations

Affiliations

  • 1 School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China. Electronic address: wliq1974@163.com.
  • 2 School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China.
PMID: 24582982 DOI: 10.1016/j.bmcl.2014.02.018
Abstract

A simple synthesis of novel 13-aryl-13H-benzo[g]benzothiazolo [2,3-b]quinazoline-5,14-dione derivatives was accomplished in excellent yields via the reaction of 2-aminobenzothiazole, aromatic aldehydes and 2-hydroxy-1,4-naphthoquinone in the presence of amberlyst-15. The antiproliferative activities of all the synthesized compounds were assessed on two different human Cancer cell lines (HepG2 and Hela), and the results showed that most of the new compounds showed good to potent cytotoxic activities.

Keywords

1,4-Naphthoquinones; 2-Hydroxy-1,4-naphthoquinone; Aldehydes; Amberlyst-15; Antiproliferative; Solvent-free.

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