2. Academic Validation
  3. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models

Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models

  • J Am Chem Soc. 2014 Mar 26;136(12):4551-6. doi: 10.1021/ja411006a.
Rachid Skouta 1,  Scott J Dixon,  Jianlin Wang,  Denise E Dunn,  Marina Orman,  Kenichi Shimada,  Paul A Rosenberg,  Donald C Lo,  Joel M Weinberg,  Andreas Linkermann,  Brent R Stockwell
Affiliations

Affiliation

  • 1 Department of Biological Sciences, Columbia University , 550 West 120th Street Northwest Corner Building, MC 4846 New York, New York 10027, United States.
PMID: 24592866 DOI: 10.1021/ja411006a
Abstract

Ferrostatin-1 (Fer-1) inhibits Ferroptosis, a form of regulated, oxidative, nonapoptotic cell death. We found that Fer-1 inhibited cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction; Fer-1 inhibited lipid peroxidation, but not mitochondrial Reactive Oxygen Species formation or lysosomal membrane permeability. We developed a mechanistic model to explain the activity of Fer-1, which guided the development of ferrostatins with improved properties. These studies suggest numerous therapeutic uses for ferrostatins, and that lipid peroxidation mediates diverse disease phenotypes.

Figures
Products