2. Academic Validation
  3. A,D-seco-limonoids from the stems of Clausena emarginata

A,D-seco-limonoids from the stems of Clausena emarginata

  • J Nat Prod. 2014 Apr 25;77(4):784-91. doi: 10.1021/np400797s.
Hong-Min Xia 1,  Chuang-Jun Li,  Jing-Zhi Yang,  Jie Ma,  Xiao-Guang Chen,  Dan Zhang,  Li Li,  Dong-Ming Zhang
Affiliations

Affiliation

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
PMID: 24593150 DOI: 10.1021/np400797s
Abstract

Twelve new A,D-seco-limonoids, clauemargines A-L (1-12), and three known analogues were isolated from the stems of Clausena emarginata. The absolute configurations of 1 and 5 were confirmed by X-ray crystallography and ECD spectroscopy, respectively. Compounds 1, 2, 8-10, and 13 showed moderate inhibitory effects on LPS-induced NO production (IC50 values<10 μM).

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