Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex

J Nat Prod. 2014 Apr 25;77(4):963-8. doi: 10.1021/np401046z.

Ikuko Nagasawa ¹, Akira Kaneko, Toshihiro Suzuki, Kazuto Nishio, Kaoru Kinoshita, Motto Shiro, Kiyotaka Koyama

Affiliations

Affiliation

1 Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University , Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan.

PMID: 24601669 DOI: 10.1021/np401046z

Abstract

One novel p-terphenyl compound, polyozellic acid (1), and its acetone adduct (3), along with a known p-terphenyl compound, thelephoric acid (2), were isolated from the mushroom Polyozellus multiplex. Their molecular structures were determined by spectroscopic analysis, X-ray crystallographic analysis, and chemical modification. In some assays related to angiogenesis, compounds 1 and 2 in particular showed inhibitory effects on proliferation, tubule formation, and invasion of human umbilical vein endothelial cells. The quinone moiety within these molecules possibly contributes to their antiangiogenesis activity.

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