2. Academic Validation
  3. Some non-conventional biomolecular targets for diamidines. A short survey

Some non-conventional biomolecular targets for diamidines. A short survey

  • Bioorg Med Chem. 2014 Apr 1;22(7):1983-92. doi: 10.1016/j.bmc.2014.02.049.
Tien L Huang 1,  Annie Mayence 1,  Jean Jacques Vanden Eynde 2
Affiliations

Affiliations

  • 1 Xavier University of Louisiana, Department of Basic Pharmaceutical Science, College of Pharmacy, 1 Drexel Drive, New Orleans, LA 70125, USA.
  • 2 University of Mons-UMONS, Laboratory of Organic Chemistry, 23 place du parc, 7000 Mons, Belgium. Electronic address: jean-jacques.vandeneynde@ex.umons.ac.be.
PMID: 24630693 DOI: 10.1016/j.bmc.2014.02.049
Abstract

Increasing the affinity of diamidines for AT-rich regions of DNA has long been an important goal of medicinal chemists who wanted to improve the antiparasitic and Antifungal properties of that class of derivatives. In recent years it was demonstrated that diamidines could interfere with many Other biomolecular targets including ion channels as well as Enzymes and modulate some RNA-protein, DNA-protein, and protein-protein interactions. It is therefore not surprising that diamidines now emerge as novel potential drug candidates for the treatment of various diseases, i.a. neurodegenerative disorders, acidosis-related pathological conditions, hypertension, thrombosis, type 2 diabetes, myotonic dystrophy, and cancers. A summary of the most striking results obtained to date in those domains is presented is this review.

Keywords

Amidines; Enzymes; Ions channels; Nucleic acid–protein interactions; Protein–protein interactions.

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