2. Academic Validation
  3. A small peptide with potential ability to promote wound healing

A small peptide with potential ability to promote wound healing

  • PLoS One. 2014 Mar 19;9(3):e92082. doi: 10.1371/journal.pone.0092082.
Jing Tang 1,  Han Liu 1,  Chen Gao 2,  Lixian Mu 1,  Shilong Yang 1,  Mingqiang Rong 3,  Zhiye Zhang 1,  Jie Liu 1,  Qiang Ding 4,  Ren Lai 3
Affiliations

Affiliations

  • 1 Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Graduate University of Chinese Academy of Sciences, Beijing, China.
  • 2 College of Veterinary Medicine of Jiangsu Animal Husbandry and Veterinary College, Taizhou, Jiangsu, China.
  • 3 Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China.
  • 4 Department of Breast Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
PMID: 24647450 DOI: 10.1371/journal.pone.0092082
Abstract

Wound-healing represents a major health burden, such as diabetes-induced skin ulcers and burning. Many works are being tried to find ideal clinical wound-healing biomaterials. Especially, small molecules with low cost and function to promote production of endogenous wound healing agents (i.e. transforming growth factor beta, TGF-β) are excellent candidates. In this study, a small peptide (tiger17, c[WCKPKPKPRCH-NH2]) containing only 11 amino acid residues was designed and proved to be a potent wound healer. It showed strong wound healing-promoting activity in a murine model of full thickness dermal wound. Tiger17 exerted significant effects on three stages of wound healing progresses including (1) the induction of macrophages recruitment to wound site at inflammatory reaction stage; (2) the promotion of the migration and proliferation both keratinocytes and fibroblasts, leading to reepithelialization and granulation tissue formation; and (3) tissue remodeling phase, by promoting the release of transforming TGF-β1 and interleukin 6 (IL-6) in murine macrophages and activating mitogen-activated protein kinases (MAPK) signaling pathways. Considering its easy production, store and transfer and function to promote production of endogenous wound healing agents (TGF-β), tiger17 might be an exciting biomaterial or template for the development of novel wound-healing agents.

Figures
Products