2. Academic Validation
  3. Structural elucidation and synthesis of vialinin C, a new inhibitor of TNF-α production

Structural elucidation and synthesis of vialinin C, a new inhibitor of TNF-α production

  • Bioorg Med Chem. 2014 Apr 15;22(8):2442-6. doi: 10.1016/j.bmc.2014.02.058.
Yue Qi Ye 1,  Chiemi Negishi 2,  Yayoi Hongo 3,  Hiroyuki Koshino 3,  Jun-ichi Onose 2,  Naoki Abe 4,  Shunya Takahashi 5
Affiliations

Affiliations

  • 1 RIKEN, Wako-shi, Saitama 351-0198, Japan; Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
  • 2 Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
  • 3 RIKEN, Wako-shi, Saitama 351-0198, Japan.
  • 4 Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan. Electronic address: abe@nodai.ac.jp.
  • 5 RIKEN, Wako-shi, Saitama 351-0198, Japan. Electronic address: shunyat@riken.jp.
PMID: 24679673 DOI: 10.1016/j.bmc.2014.02.058
Abstract

A new inhibitor of TNF-α production (IC50=0.89 μM) named vialinin C (1) was isolated from dry fruiting bodies of an edible Chinese mushroom, Thelephora vialis. The structure of 1 was determined by high-resolution MS, NMR spectroscopic analysis, and confirmed by synthesis. Synthesis of ganbajunin B (5) obtained from the same origin was also described.

Keywords

TNF-α; Vialinin A; Vialinin B; Vialinin C.

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