Cepharanthine inhibited HIV-1 cell-cell transmission and cell-free infection via modification of cell membrane fluidity

Bioorg Med Chem Lett. 2014 May 1;24(9):2115-7. doi: 10.1016/j.bmcl.2014.03.041.

Kouki Matsuda ¹, Shinichiro Hattori ¹, Yuji Komizu ², Ryusho Kariya ¹, Ryuichi Ueoka ², Seiji Okada ³

Affiliations

1 Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
2 Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan.
3 Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan. Electronic address: okadas@kumamoto-u.ac.jp.

PMID: 24704028 DOI: 10.1016/j.bmcl.2014.03.041

Abstract

The anti-HIV-1 activity of cepharanthine (CEP), a natural product derived from Stephania cepharantha Hayata, was evaluated. CEP stabilized plasma membrane fluidity and inhibited HIV-1 envelope-dependent cell-to-cell fusion of HIV-1-infected cells as well as cell-free Infection. It is suggested that CEP inhibited the HIV-1 entry process by reducing plasma membrane fluidity, and the plasma membrane is therefore an identical target to prevent viral Infection.

Keywords

Cell fusion; Cepharanthine; HIV-1; Membrane fluidity; Viral infection.

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