Synthesis of 6-cinnamoyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and their effects on A549 lung cancer cell growth

Eur J Med Chem. 2014 May 22:79:95-101. doi: 10.1016/j.ejmech.2014.03.087.

Xue-Wen Zhou ¹, Han-Lin Ma ², Xuan Zhang ¹, Shi-Yao Jing ¹, Jun-Ying Miao ³, Bao-Xiang Zhao ⁴

Affiliations

1 Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China.
2 Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, PR China.
3 Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, PR China. Electronic address: miaojy@sdu.edu.cn.
4 Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China. Electronic address: bxzhao@sdu.edu.cn.

PMID: 24727462 DOI: 10.1016/j.ejmech.2014.03.087

Abstract

A series of novel 6-cinnamoyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives was synthesized. The structures of compounds were characterized by (1)H NMR, IR, and MS. Moreover, representative crystal structure was determined by X-ray diffraction analysis. The preliminary biological evaluation of all these compounds showed that compounds 3a-3d would suppress the growth of A549 lung cells effectively by inducing Autophagy and cell cycle arrest.

Keywords

A549 lung cells; Autophagy; Benzoxazinone; Chalcone.

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