2. Academic Validation
  3. Anti-inflammatory activity of diterpene alkaloids from Aconitum baikalense

Anti-inflammatory activity of diterpene alkaloids from Aconitum baikalense

  • Bull Exp Biol Med. 2014 Mar;156(5):665-8. doi: 10.1007/s10517-014-2421-4.
Yu V Nesterova 1,  T N Povetieva,  N I Suslov,  G N Zyuz'kov,  S G Aksinenko,  S V Pushkarskii,  A V Krapivin
Affiliations

Affiliation

  • 1 Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, nes-yuliya@yandex.ru.
PMID: 24770754 DOI: 10.1007/s10517-014-2421-4
Abstract

We compared anti-inflammatory activity of individual diterpene Alkaloids isolated from Aconitum baikalense (napelline, songorine, hypaconitine, mesaconitine, 12-epinapelline N-oxide) under conditions of acute inflammation of different genesis. The tested substances showed high antiexudative activity comparable with that of sodium diclofenac. Unlike nonsteroidal anti-inflammatory drugs, diterpene Alkaloids exerted no ulcerogenic effect.

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