2. Academic Validation
  3. Asymmetric syntheses and bio-evaluation of novel chiral esters derived from substituted tetrafluorobenzyl alcohol

Asymmetric syntheses and bio-evaluation of novel chiral esters derived from substituted tetrafluorobenzyl alcohol

  • Bioorg Med Chem Lett. 2014 Jun 15;24(12):2734-6. doi: 10.1016/j.bmcl.2014.04.055.
Shengzhen Xu 1,  Huangyong Li 1,  Xiaohui Wang 1,  Changshui Chen 1,  Minhui Cao 1,  Xiufang Cao 2
Affiliations

Affiliations

  • 1 College of Science, Huazhong Agricultural University, Wuhan 430070, China.
  • 2 College of Science, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: caoxiufang@mail.hzau.edu.cn.
PMID: 24794106 DOI: 10.1016/j.bmcl.2014.04.055
Abstract

A series of novel chiral esters derived from tetrafluorobenzyl alcohol were designed and prepared via asymmetric synthesis. The target molecules have been identified on the basis of analytical spectra data. All newly synthesized compounds have been screened their potential insecticidal activity against Plutella xylostella compared with those of fenvalerate and d-trans-phenothrin by standard method, and the respective pairs of enantiomers (3-B1-R/S, 3-C1-R/S, 3-D1-R/S) indicated significantly different activities.

Keywords

Activities; Asymmetric syntheses; Chiral esters; Tetrafluorobenzyl alcohol.

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