2. Academic Validation
  3. Design, synthesis and biological evaluation of small molecular polyphenols as entry inhibitors against H(5)N(1)

Design, synthesis and biological evaluation of small molecular polyphenols as entry inhibitors against H(5)N(1)

  • Bioorg Med Chem Lett. 2014 Jun 15;24(12):2680-4. doi: 10.1016/j.bmcl.2014.04.057.
Jian Yang 1,  Jing Xiang Yang 2,  Fang Zhang 3,  Gang Chen 3,  Wei Pan 4,  Rui Yu 3,  Shuwen Wu 5,  Po Tien 6
Affiliations

Affiliations

  • 1 Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: Yanj502@sohu.com.
  • 2 Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, China; Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China; School of Pharmaceutical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
  • 3 Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, China; Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.
  • 4 The College of Life Sciences, State Key Laboratory of Virology, Modern Virology Research Center, Wuhan University, Wuhan 430072, China.
  • 5 The College of Life Sciences, State Key Laboratory of Virology, Modern Virology Research Center, Wuhan University, Wuhan 430072, China. Electronic address: shuwenwu@hotmail.com.
  • 6 The College of Life Sciences, State Key Laboratory of Virology, Modern Virology Research Center, Wuhan University, Wuhan 430072, China. Electronic address: tienpo@sun.im.ac.cn.
PMID: 24803363 DOI: 10.1016/j.bmcl.2014.04.057
Abstract

To find novel compounds against H5N1, three series of known or novel small molecular Polyphenols were synthesized and tested in vitro for anti-H5N1 activity. In addition, the preliminary structure-antiviral activity relationships were elaborated. The results showed that some small molecular Polyphenols had better anti-H5N1 activity, and could serve as novel virus entry inhibitors against H5N1, likely targeting to HA2 protein. Noticeably, compound 4a showed the strongest activity against H5N1 among these compounds, and the molecular modeling analysis also suggested that this compound might target to HA2 protein. Therefore, compound 4a is well qualified to serve as a lead compound or scaffold for the further development of H5N1 entry inhibitor.

Keywords

Anti-H(5)N(1) activity; Entry inhibitor; HA2; Molecular modeling; Small molecular polyphenols; Synthesis.

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