2. Academic Validation
  3. Dammarane-type triterpenoids from Gentianella azurea

Dammarane-type triterpenoids from Gentianella azurea

  • J Nat Prod. 2014 May 23;77(5):1201-9. doi: 10.1021/np500077z.
Yu-jie Huang 1,  Hui Lu,  Xue-li Yu,  Shu-wei Zhang,  Wen-qiong Wang,  Lin-yin Fen,  Li-jiang Xuan
Affiliations

Affiliation

  • 1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
PMID: 24806310 DOI: 10.1021/np500077z
Abstract

Thirteen new dammarane-type triterpenoids (1-13) and four known analogues, gentirigenic acid (14) and the gentirigeosides A, B, and E (15-17), were isolated from Gentianella azurea. Their structures were elucidated by detailed analysis of the NMR, MS, and X-ray crystallographic data. This is the first report of dammarane-type triterpenoids in the Gentianella genus. In addition, the known structures of gentirigenic acid (14) and the gentirigeosides A, B, and E (15-17) were revised based on the X-ray diffraction analysis. Gentirigeoside A (15) was found to inhibit nitric oxide production in RAW 264.7 macrophages with an IC50 value of 6.6 ± 2.1 μM.

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