2. Academic Validation
  3. Pyranocoumarins from Glehnia littoralis inhibit the LPS-induced NO production in macrophage RAW 264.7 cells

Pyranocoumarins from Glehnia littoralis inhibit the LPS-induced NO production in macrophage RAW 264.7 cells

  • Bioorg Med Chem Lett. 2014 Jun 15;24(12):2717-9. doi: 10.1016/j.bmcl.2014.04.046.
Jin Woo Lee 1,  Chul Lee 1,  Qinghao Jin 1,  Eung Tae Yeon 1,  Dongho Lee 2,  Soo-Young Kim 3,  Sang Bae Han 1,  Jin Tae Hong 1,  Mi Kyeong Lee 1,  Bang Yeon Hwang 4
Affiliations

Affiliations

  • 1 College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.
  • 2 College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea.
  • 3 Wildlife Genetic Resources Center, National Institute of Biological Resources, Incheon 404-708, Republic of Korea.
  • 4 College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea. Electronic address: byhwang@chungbuk.ac.kr.
PMID: 24813739 DOI: 10.1016/j.bmcl.2014.04.046
Abstract

A new dihydropyranocoumarin, (+)-cis-(3'S,4'S)-diisobutyrylkhellactone (1), together with five known compounds, 3'-senecioyl-4'-acetylkhellactone (2), 3'-isovaleryl-4'-acetylkhellactone (3), 3',4'-disenecioylkhellactone (4), 3'-isovaleryl-4'-senecioylkhellactone (5), and 3',4'-diisovalerylkhellactone (6), was isolated from Glehnia littoralis. Their chemical structures were elucidated based on the spectroscopic data interpretation, particularly 1D and 2D NMR data including HMQC and HMBC. All the isolated compounds showed the potential to inhibit LPS-induced nitric oxide production in RAW 264.7 cells with IC50 values ranging from 7.4 to 44.3μM.

Keywords

Apiaceae; Dihydropyranocoumarin; Glehnia littoralis; Nitric oxide production inhibitor.

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