2. Academic Validation
  3. Three new cembranoid-type diterpenes from Red Sea soft coral Sarcophyton glaucum: isolation and antiproliferative activity against HepG2 cells

Three new cembranoid-type diterpenes from Red Sea soft coral Sarcophyton glaucum: isolation and antiproliferative activity against HepG2 cells

  • Eur J Med Chem. 2014 Jun 23:81:314-22. doi: 10.1016/j.ejmech.2014.05.016.
Sultan S Al-Lihaibi 1,  Walied M Alarif 1,  Ahmed Abdel-Lateff 2,  Seif-Eldin N Ayyad 3,  Ashraf B Abdel-Naim 4,  Fardous F El-Senduny 5,  Farid A Badria 6
Affiliations

Affiliations

  • 1 Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, P.O. Box 80207, Jeddah 21589, Saudi Arabia.
  • 2 Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, P.O. Box 80260, Jeddah 21589, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. Electronic address: ahmedabdellateff@yahoo.com.
  • 3 Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
  • 4 Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, P.O. Box 80260, Jeddah 21589, Saudi Arabia.
  • 5 Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt.
  • 6 Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
PMID: 24852278 DOI: 10.1016/j.ejmech.2014.05.016
Abstract

Three new cembranoids: sarcophytolol (1), sarcophytolide B (2), and sarcophytolide C (3), along with three known metabolites: 10(14)aromadendrene (4), deoxosarcophine (5), and sarcophine (6) were obtained from the soft bodied coral Sarcophyton glaucum. The structures were determined based on spectroscopic measurements (NMR, UV, IR and MS). Compounds 1, 3, and 4 had similar significant cytotoxic effects towards HepG2 (Human hepatocellular liver carcinoma; IC50 = 20 μM). 2 and 3 showed activity against MCF-7 (Human breast adenocarcinoma; IC50 25 ± 0.0164 and 29 ± 0.030 μM, respectively). Finally, 4 showed potent activity towards PC-3 (Prostate cancer; IC50 9.3 ± 0.164 μM). The antiproliferative activity of 1, 3 and 4, can be attributed, at least partly, to their ability to induce cellular Apoptosis.

Keywords

Antiproliferative; Cembranes; HepG2; PC-3; Sarcophyton.

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