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  3. Dibenzocyclooctadiene lignans from Schisandra chinensis and their inhibitory activity on NO production in lipopolysaccharide-activated microglia cells

Dibenzocyclooctadiene lignans from Schisandra chinensis and their inhibitory activity on NO production in lipopolysaccharide-activated microglia cells

  • Phytochemistry. 2014 Aug:104:72-8. doi: 10.1016/j.phytochem.2014.04.014.
Di Hu 1,  Zhiyou Yang 1,  Xuechun Yao 2,  Hua Wang 1,  Na Han 1,  Zhihui Liu 1,  Yu Wang 3,  Jingyu Yang 2,  Jun Yin 4
Affiliations

Affiliations

  • 1 Development and Utilization Key Laboratory of Northeast Plant Materials of Liaoning Province, Department of Pharmacognosy, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • 2 Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • 3 The Chinese People's Liberation Army 463 Hospital, Shenyang 110042, China.
  • 4 Development and Utilization Key Laboratory of Northeast Plant Materials of Liaoning Province, Department of Pharmacognosy, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: yinjun2002@yahoo.com.
PMID: 24864016 DOI: 10.1016/j.phytochem.2014.04.014
Abstract

Four dibenzocyclooctadiene Lignans, schisanchinins A-D, and 10 known compounds were isolated from the EtOAc extract of fruits of Schisandra chinensis (Turcz.) Baill. Structures of compounds 1-4 were elucidated using a combination of spectroscopic techniques, including MS, UV and IR, NMR ((1)H NMR, (13)C NMR, HMQC, HMBC). The stereochemistry of the chiral centers and the biphenyl configuration were determined using NOESY, as well as analysis of CD spectra. In vitro activity assays showed that 11 of the 14 compounds exhibited inhibitory activity on lipopolysaccharide (LPS)-induced NO release in primary murine BV2 microglia cells.

Keywords

Dibenzocyclooctadiene lignans; Inhibitory activity on lipopolysaccharide (LPS)-induced NO release; Schisandra chinensis; Schisandraceae.

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