2. Academic Validation
  3. AS2077715: a novel antifungal antibiotic produced by Capnodium sp. 339855

AS2077715: a novel antifungal antibiotic produced by Capnodium sp. 339855

  • J Antibiot (Tokyo). 2014 Oct;67(10):707-11. doi: 10.1038/ja.2014.69.
Keisuke Ohsumi 1,  Teruhisa Masaki 2,  Shigehiro Takase 1,  Masato Watanabe 1,  Akihiko Fujie 1
Affiliations

Affiliations

  • 1 Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan.
  • 2 Fermentation Research Division, Astellas Research Technologies Co., Ltd., Ibaraki, Japan.
PMID: 24865863 DOI: 10.1038/ja.2014.69
Abstract

A novel Antifungal agent, AS2077715, was isolated from the fermentation broth of a Fungal strain (339855) identified as a new Capnodium species based on morphological characteristics and large-subunit ribosomal DNA sequencing. AS2077715 was isolated as a white powder via solvent extraction, HP-20 and ODS-B column chromatography and crystallization, and was determined to have the molecular formula C25H41NO7. AS2077715 has a structure related to that of funiculosin, an inhibitor of mitochondrial cytochrome bc1 complex (complex III), and showed Antifungal activity against Trichophyton species.

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