2. Academic Validation
  3. Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors

Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors

  • Medchemcomm. 2013 Apr 1;2013(4):693-696. doi: 10.1039/C3MD00068K.
Sebastian Trousil # 1,  Laurence Carroll # 1,  Andrew Kalusa 1,  Ola Aberg 1,  Maciej Kaliszczak 1,  Eric O Aboagye 1
Affiliations

Affiliation

  • 1 Comprehensive Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Campus, Imperial College, London, UK.
  • # Contributed equally.
PMID: 24976941 DOI: 10.1039/C3MD00068K
Abstract

Choline kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising Cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described.

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