2. Academic Validation
  3. The molecular basis of IL-10 function: from receptor structure to the onset of signaling

The molecular basis of IL-10 function: from receptor structure to the onset of signaling

  • Curr Top Microbiol Immunol. 2014;380:191-212. doi: 10.1007/978-3-662-43492-5_9.
Mark R Walter 1
Affiliations

Affiliation

  • 1 Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA, walter@uab.edu.
PMID: 25004819 DOI: 10.1007/978-3-662-43492-5_9
Abstract

Assembly of the cell surface IL-10 Receptor complex is the first step in initiating IL-10 signaling pathways that regulate intestinal inflammation, viral persistence and even tumor surveillance. The discovery of IL-10 homologs in the genomes of herpes viruses suggests IL-10 signaling pathways can be manipulated at the level of the receptor complex. This chapter will describe our current molecular understanding of IL-10 Receptor assembly based on crystal structures and biochemical analyses of cellular and viral IL-10 Receptor complexes.

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