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  3. "On water" expedient synthesis of 3-indolyl-3-hydroxy oxindole derivatives and their anticancer activity in vitro

"On water" expedient synthesis of 3-indolyl-3-hydroxy oxindole derivatives and their anticancer activity in vitro

  • Eur J Med Chem. 2014 Sep 12:84:155-9. doi: 10.1016/j.ejmech.2014.07.004.
Parvathaneni Sai Prathima 1,  Pamanji Rajesh 2,  Janapala Venkateswara Rao 2,  Uppalapati Sai Kailash 3,  Balasubramanian Sridhar 4,  Mandapati Mohan Rao 5
Affiliations

Affiliations

  • 1 Inorganic & Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad 500607, India.
  • 2 Biology Division, Indian Institute of Chemical Technology, Hyderabad 500607, India.
  • 3 National Centre for Cell Sciences, University of Pune Campus, Ganeshkhind, Pune 411007, India.
  • 4 X-ray Crystallography Division, Indian Institute of Chemical Technology, Hyderabad 500607, India.
  • 5 Inorganic & Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad 500607, India. Electronic address: mandapati@iict.res.in.
PMID: 25016373 DOI: 10.1016/j.ejmech.2014.07.004
Abstract

A series of 3-indolyl-3-hydroxy oxindole derivatives (n = 41) were synthesized by the green aminocatalytic method with excellent yields under mild reaction conditions. All the newly synthesized derivatives were subjected to evaluate their cytotoxic properties against different human Cancer cell lines. Results indicated that about 73% of the derivatives exhibited significant anti-proliferative activities against leukemia (U937, THP-1), lung (A549) and breast Cancer (MCF7) cell lines. Among them a few of the derivatives exhibited the most potent and effective cytotoxic activities on U937 (34, 36, 38 and 41) and MCF7 (12, 35, 40 and 41) cell lines, and their anti-proliferation activities are better than the positive control, Etoposide.

Keywords

3-Indolyl-3-hydroxy oxindoles; Cytotoxicity; Diethanolamine; Indole; Isatin; Water.

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