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  3. Study on one-pot four-component synthesis of 9-aryl-hexahydro-acridine-1,8-diones using SiO2-I as a new heterogeneous catalyst and their anticancer activity

Study on one-pot four-component synthesis of 9-aryl-hexahydro-acridine-1,8-diones using SiO2-I as a new heterogeneous catalyst and their anticancer activity

  • Bioorg Med Chem Lett. 2014 Aug 15;24(16):3907-13. doi: 10.1016/j.bmcl.2014.06.047.
K B Ramesh 1,  M A Pasha 2
Affiliations

Affiliations

  • 1 Department of Studies in Chemistry, Central College Campus, Palace Road, Bangalore University, Bengaluru 560001, India.
  • 2 Department of Studies in Chemistry, Central College Campus, Palace Road, Bangalore University, Bengaluru 560001, India. Electronic address: m_af_pasha@ymail.com.
PMID: 25042338 DOI: 10.1016/j.bmcl.2014.06.047
Abstract

A simple, efficient and cost-effective method for the synthesis of 9-aryl-hexahydro-acridine-1,8-diones by a one-pot four-component cyclocondensation of dimedone, aromatic aldehydes and ammonium acetate as a nitrogen source in the presence of a new heterogeneous catalyst silica iodide (SiO2-I) in EtOH at 80 °C is described. SiO2-I was subjected to SEM-EDX and found to have iodo group bound to the catalyst. Some of the prepared acridine-diones were found to exhibit promising anti-cancer activity against HepG2 and MCF-7 cell lines.

Keywords

9-Aryl-hexahydro-acridine-1,8-diones; Ammonium acetate; Anticancer activity; Aromatic aldehydes; Dimedone; Silica iodide.

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