Neuroprotective Xanthones from the Root Bark of Cudrania tricuspidata

J Nat Prod. 2014 Aug 22;77(8):1893-901. doi: 10.1021/np500364x.

Jaeyoung Kwon ¹, Nguyen Tuan Hiep ¹, Dong-Woo Kim ², Bang Yeon Hwang ³, Hak Ju Lee ⁴, Woongchon Mar ², Dongho Lee ¹

Affiliations

1 Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University , Seoul 136-713, Korea.
2 Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 151-742, Korea.
3 College of Pharmacy, Chungbuk National University , Cheongju 361-763, Korea.
4 Korea Forest Research Institute , Seoul 130-712, Korea.

PMID: 25051453 DOI: 10.1021/np500364x

Abstract

Seventeen new prenylated Xanthones (1-17) were isolated from an ethyl acetate-soluble extract of root bark of Cudrania tricuspidata together with 17 previously identified Xanthones. The structures of the new compounds were elucidated by spectroscopic methods. Six new compounds (3, 7, 8, 9, 15, and 16) and six known compounds (18-23) showed neuroprotective effects against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.7-16.6 μM.

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