2. Academic Validation
  3. Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia

Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia

  • Bioorg Med Chem Lett. 2014 Aug 15;24(16):3835-40. doi: 10.1016/j.bmcl.2014.06.058.
SeonJu Park 1,  Nguyen Xuan Nhiem 2,  Phan Van Kiem 3,  Chau Van Minh 3,  Bui Huu Tai 3,  Nanyoung Kim 1,  Hye Hyun Yoo 4,  Jae-Hyoung Song 5,  Hyun-Jeong Ko 5,  Seung Hyun Kim 6
Affiliations

Affiliations

  • 1 College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon 406-840, Republic of Korea.
  • 2 College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon 406-840, Republic of Korea; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 3 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 4 Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 426-791, Republic of Korea.
  • 5 Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon 200-701, Republic of Korea.
  • 6 College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon 406-840, Republic of Korea. Electronic address: kimsh11@yonsei.ac.kr.
PMID: 25066952 DOI: 10.1016/j.bmcl.2014.06.058
Abstract

Eurycoma longifolia has been widely used for various traditional medicinal purposes in South-East Asia. In this study, five new quassinoids, eurylactone E (1), eurylactone F (2), eurylactone G (3), eurycomalide D (4), and eurycomalide E (5), along with ten known quassinoids (6-15) were isolated from the roots of E. longifolia. Their structures were determined by extensive spectroscopic methods, including 1D and 2D NMR, and MS spectra data. Among the isolated compounds, 13β-methyl,21-dihydroeurycomanone (6) has been reported as a synthetic derivative. However, it was isolated from the natural product for the first time in this study. The cytotoxic activities of fifteen compounds were evaluated against human lung Cancer cell line, A549 and human cervical Cancer cell line, HeLa.

Keywords

A549 (human lung cancer cell); Cytotoxicity; Eurycoma longifolia; HeLa (human cervical cancer cell); Quassinoid.

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