2. Academic Validation
  3. Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria

Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria

  • J Nat Prod. 2014 Aug 22;77(8):1937-41. doi: 10.1021/np500399v.
Yongxiang Song 1,  Qinglian Li 1,  Xue Liu 2,  Yuchan Chen 3,  Yun Zhang 1,  Aijun Sun 1,  Weimin Zhang 3,  Jingren Zhang 2,  Jianhua Ju 1
Affiliations

Affiliations

  • 1 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, China.
  • 2 Center for Infectious Disease Research, School of Medicine, Tsinghua University , Beijing 100084, China.
  • 3 Guangdong Institute of Microbiology , 100 Central Xianlie Road, Guangzhou 510070, China.
PMID: 25072108 DOI: 10.1021/np500399v
Abstract

Three new cyclohexapeptides, desotamides B-D (2-4), and the known desotamide (1) were isolated from marine microbe Streptomyces scopuliridis SCSIO ZJ46. The sequences and absolute configurations of 2-4 were elucidated on the basis of high-resolution spectroscopic data, Marfey's method, and chiral-phase HPLC data. Desotamide C (3) contains a unique N-formyl-kynurenine residue, whereas 4 lacks formylation at the same site. Compounds 1 and 2 displayed notable Antibacterial activities against strains of Streptococcus pnuemoniae, Staphylococcus aureus, and methicillin-resistant Staphylococcus epidermidis (MRSE), and structure activity relationship studies revealed the indispensability of the Trp component for Antibacterial activity within this new scaffold.

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