2. Academic Validation
  3. Physiological roles of the pantothenate kinases

Physiological roles of the pantothenate kinases

  • Biochem Soc Trans. 2014 Aug;42(4):1033-6. doi: 10.1042/BST20140096.
Lorraine E Dansie 1,  Stacy Reeves 1,  Karen Miller 1,  Stephen P Zano 1,  Matthew Frank 1,  Caroline Pate 1,  Jina Wang 1,  Suzanne Jackowski 1
Affiliations

Affiliation

  • 1 *Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, U.S.A.
PMID: 25109998 DOI: 10.1042/BST20140096
Abstract

CoA (coenzyme A) is an essential cofactor that is involved in many metabolic processes. CoA is derived from pantothenate in five biosynthetic reactions. The CoA biosynthetic pathway is regulated by PanKs (pantothenate kinases) and four active isoforms are expressed in mammals. The critical physiological functions of the PanKs are revealed by systematic deletion of the Pank genes in mice.

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