2. Academic Validation
  3. Analgesic activity of diterpene alkaloids from Aconitum baikalensis

Analgesic activity of diterpene alkaloids from Aconitum baikalensis

  • Bull Exp Biol Med. 2014 Aug;157(4):488-91. doi: 10.1007/s10517-014-2598-6.
Yu V Nesterova 1,  T N Povet'yeva,  N I Suslov,  G N Zyuz'kov,  S V Pushkarskii,  S G Aksinenko,  E E Schultz,  S S Kravtsova,  A V Krapivin
Affiliations

Affiliation

  • 1 E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, nes-yuliya@yandex.ru.
PMID: 25110090 DOI: 10.1007/s10517-014-2598-6
Abstract

We compared analgesic activities of individual Alkaloids extracted from Baikal aconite (Aconitum baikalensis): napelline, hypaconitine, songorine, mesaconitine, 12-epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were different in diterpene Alkaloids of different structure. The antinociceptive effect of atisine Alkaloids (12-epinapelline N-oxide, songorine) was naloxonedependent and realized via Opioid Receptor modulation.

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