2. Academic Validation
  3. Evaluation of molecules based on the electron donor-acceptor architecture as near-infrared β-amyloidal-targeting probes

Evaluation of molecules based on the electron donor-acceptor architecture as near-infrared β-amyloidal-targeting probes

  • Chem Commun (Camb). 2014 Oct 14;50(80):11875-8. doi: 10.1039/c4cc04907a.
Hualong Fu 1,  Mengchao Cui,  Peiyu Tu,  Ziwei Pan,  Boli Liu
Affiliations

Affiliation

  • 1 Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China. cmc@bnu.edu.cn.
PMID: 25156492 DOI: 10.1039/c4cc04907a
Abstract

A novel class of near-infrared molecules based on the donor-acceptor architecture were synthesized and evaluated as Aβ imaging probes. In vivo imaging studies suggested that MCAAD-3 could penetrate the blood-brain barrier and label Aβ plaques in the brains of transgenic mice. Computational studies could reproduce the experimental trends well.

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