2. Academic Validation
  3. Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes

Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes

  • Comp Biochem Physiol Part D Genomics Proteomics. 2014 Sep;11:45-8. doi: 10.1016/j.cbd.2014.08.001.
Donald L Puppione 1
Affiliations

Affiliation

  • 1 The Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA. Electronic address: puppione@chem.ucla.edu.
PMID: 25160599 DOI: 10.1016/j.cbd.2014.08.001
Abstract

Previous studies have demonstrated that the apoC-I gene and its pseudogene on human chromosome 19 are flanked by a duplicate set of enhancers. Multienhancers, ME.1 and ME.2, are located upstream from the genes and the hepatic control region enhancers, HCR.1 and HCR.2, are located downstream. The duplication of the enhancers has been thought to have occurred when the apoC-I gene was duplicated during primate evolution. Currently, the only primate data are for the human enhancers. Examining the genome of Other primates (great and lesser apes, Old and New World monkeys), it was possible to locate the duplicate set of enhancers in apes and Old World monkeys. However, only a single set was found in New World monkeys. These observations provide additional evidence that the apoC-I gene and the flanking enhancers underwent duplication after the divergence of Old and New World monkeys.

Keywords

Enhancer duplication; Primates; Pseudogene.

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