Melatonin: exceeding expectations

Physiology (Bethesda). 2014 Sep;29(5):325-33. doi: 10.1152/physiol.00011.2014.

Russel J Reiter ¹, Dun Xian Tan ², Annia Galano ³

Affiliations

1 Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas; and reiter@uthscsa.edu.
2 Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas; and.
3 Departamento de Quimica, Universidad Autonoma Metropolitana-Iztapalapa, Mexico D.F., Mexico.

PMID: 25180262 DOI: 10.1152/physiol.00011.2014

Abstract

Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and Cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing radiation, and drug toxicity, among Others. Melatonin has numerous applications in physiology and medicine.

Name
Email *

	Sorry, but the email address you supplied was invalid.