2. Academic Validation
  3. Isolation and identification of aromatic compounds in Lion's Mane Mushroom and their anticancer activities

Isolation and identification of aromatic compounds in Lion's Mane Mushroom and their anticancer activities

  • Food Chem. 2015 Mar 1:170:336-42. doi: 10.1016/j.foodchem.2014.08.078.
Wei Li 1,  Wei Zhou 2,  Eun-Ji Kim 3,  Sang Hee Shim 4,  Hee Kyoung Kang 5,  Young Ho Kim 6
Affiliations

Affiliations

  • 1 School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Republic of Korea.
  • 2 College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
  • 3 School of Medicine and Institute of Medical Science, Jeju National University, Jeju 690-756, Republic of Korea.
  • 4 School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Republic of Korea. Electronic address: shshim29@ynu.ac.kr.
  • 5 School of Medicine and Institute of Medical Science, Jeju National University, Jeju 690-756, Republic of Korea. Electronic address: pharmkhk@jejunu.ac.kr.
  • 6 College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea. Electronic address: yhk@cnu.ac.kr.
PMID: 25306354 DOI: 10.1016/j.foodchem.2014.08.078
Abstract

Lion's Mane Mushroom (Hericium erinaceum) is a traditional edible mushroom widely used in culinary applications and as an herbal medicine in East Asian countries. In the present study, two new aromatic compounds, hericerin A (1) and isohericenone J (5), along with five known compounds, isoericerin (2), hericerin (3), N-De phenylethyl isohericerin (4), hericenone J (6), and 4-[3',7'-dimethyl-2',6'-octadienyl]-2-formyl-3-hydroxy-5-methyoxybenzylalcohol (7), were isolated from a methanol extract of the fruiting bodies of H. erinaceum. The chemical structures of the compounds were determined from mass spectra and 1D- and 2D NMR spectroscopy. The Anticancer effects of the isolated compounds were examined in HL-60 human acute promyelocytic leukaemia cells. Hericerin A (1) and hericerin (3) significantly reduced cell proliferation with IC50 values of 3.06 and 5.47 μM, respectively. These same compounds also induced Apoptosis of HL-60 cells, accompanied by time-dependent down-regulation of p-AKT and c-Myc levels. These data suggest that compounds 1 and 3 from H. erinaceum are suitable for use in potential Cancer treatments.

Keywords

Anticancer activity; Apoptosis; Hericerin A; Hericiaceae; Hericium erinaceum; Isohericenone J.

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