2. Academic Validation
  3. Terpenoids from the root bark of Pterolobium macropterum

Terpenoids from the root bark of Pterolobium macropterum

  • J Nat Prod. 2014 Nov 26;77(11):2432-7. doi: 10.1021/np500476h.
Jittra Suthiwong 1,  Siripit Pitchuanchom,  Wareeporn Wattanawongdon,  Chariya Hahnvajanawong,  Chavi Yenjai
Affiliations

Affiliation

  • 1 Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, and §Department of Microbiology, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University , Khon Kaen 40002, Thailand.
PMID: 25337628 DOI: 10.1021/np500476h
Abstract

Five new compounds, including pteroloterins A-C (1, 3, and 4), 1β-acetoxytaepeenin C (2), and 8aα-hydroxycadinenal (5), and 11 known compounds were isolated from the root bark of Pterolobium macropterum. All compounds were evaluated for cytotoxicity against the cholangiocarcinoma cell lines. Compound 9 showed weak cytotoxicity against the KKU-M139 cell line with an IC50 value of 23.24 ± 0.18 μM and showed no activity against normal cells.

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