New anti-inflammatory tocopherol-derived metabolites from the Taiwanese soft coral Cladiella hirsuta

Bioorg Med Chem Lett. 2015 Jan 1;25(1):92-5. doi: 10.1016/j.bmcl.2014.11.002.

Bo-Wei Chen ¹, Chokkalingam Uvarani ¹, Chiung-Yao Huang ¹, Tsong-Long Hwang ², Chang-Feng Dai ³, Jyh-Horng Sheu ⁴

Affiliations

1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
2 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
3 Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan.
4 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan; Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan. Electronic address: sheu@mail.nsysu.edu.tw.

PMID: 25434002 DOI: 10.1016/j.bmcl.2014.11.002

Abstract

Two new tocopherol-derived metabolites, hirsutocospiro A (1) and hirsutocoquinone A (2), were isolated from the soft coral Cladiella hirsuta. The structures of 1 and 2 were determined by extensive spectroscopic analysis. The in vitro anti-inflammatory activity of compounds 1 and 2 was evaluated by measuring their ability in suppressing superoxide anion generation and Elastase release in fMLP/CB-induced human neutrophils. Compound 1 was shown to exhibit significant anti-inflammatory activity.

Keywords

Anti-inflammatory activity; Cladiella hirsuta; Hirsutaquinone.

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