2. Academic Validation
  3. Immunotoxicity effects of carbaryl in vivo and in vitro

Immunotoxicity effects of carbaryl in vivo and in vitro

  • Environ Toxicol Pharmacol. 2014 Nov;38(3):838-44. doi: 10.1016/j.etap.2014.09.004.
Seyed Gholam Ali Jorsaraei 1,  Ghorban Maliji 2,  Abbas Azadmehr 3,  Ali Akbar Moghadamnia 4,  Ali Akbar Faraji 5
Affiliations

Affiliations

  • 1 Fatemeh Zahra Infertility Research Center, Babol University of Medical Sciences, Babol, Iran.
  • 2 Department of Immunology, Babol University of Medical Sciences, Babol, Iran.
  • 3 Department of Immunology, Qazvin University of Medical Sciences, Qazvin, Iran. Electronic address: azadmehr2014@gmail.com.
  • 4 Department of Pharmacology and Physiology, Babol University of Medical Sciences, Babol, Iran.
  • 5 Medical School, Babol University of Medical Sciences, Babol, Iran.
PMID: 25461543 DOI: 10.1016/j.etap.2014.09.004
Abstract

Carbaryl is a pesticide for controlling pests in agricultural industry. To determine of immunotoxicity effects of carbaryl, rats were exposure with carbaryl for 28 days. The lymphoid organ weight, lymphocyte proliferation, IL-2, IFN-γ, IL-4, IL-10, IL-1β and TNF-α cytokines level were measured, respectively. Exposure with carbaryl significantly reduced both thymus and spleen weight and also suppressed lymphocyte proliferation. In addition, carbaryl significantly decreased IL-2, IFN-γ, IL-1β and TNF-α and also increased IL-4, IL-10 cytokines. These findings suggest that exposure to carbaryl can induce immunotoxicity effects on lymphoid organ weight, suppresses the functions of lymphocyte and macrophage, Th2 polarization in Th1/Th2 balance by reducing of IFN-γ and increasing of IL-4 and IL-10 cytokines. Therefore, carbaryl can contribute to the development of allergic, autoimmune, Cancer or Infection diseases through immunotoxicity effects and unbalancing of Th1/Th2 immune response however, further study is necessary.

Keywords

Carbaryl; Cytokines; Immunotoxicity; Lymphocyte; Macrophage; Th1/Th2.

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