2. Academic Validation
  3. The role of Pyruvate Dehydrogenase Complex in cardiovascular diseases

The role of Pyruvate Dehydrogenase Complex in cardiovascular diseases

  • Life Sci. 2015 Jan 15;121:97-103. doi: 10.1016/j.lfs.2014.11.030.
Wanqing Sun 1,  Quan Liu 1,  Jiyan Leng 1,  Yang Zheng 1,  Ji Li 2
Affiliations

Affiliations

  • 1 Division of Cardiovascular Medicine, The First Hospital of Jilin University, Changchun 130021, China.
  • 2 Division of Cardiovascular Medicine, The First Hospital of Jilin University, Changchun 130021, China. Electronic address: jli23@jlu.edu.cn.
PMID: 25498896 DOI: 10.1016/j.lfs.2014.11.030
Abstract

The regulation of mammalian myocardial carbohydrate metabolism is complex; many factors such as arterial substrate and hormone levels, coronary flow, inotropic state and the nutritional status of the tissue play a role in regulating mammalian myocardial carbohydrate metabolism. The Pyruvate Dehydrogenase Complex (PDHc), a mitochondrial matrix multienzyme complex, plays an important role in energy homeostasis in the heart by providing the link between glycolysis and the tricarboxylic acid (TCA) cycle. In TCA cycle, PDHc catalyzes the conversion of pyruvate into acetyl-CoA. This review determines that there is altered cardiac glucose in various pathophysiological states consequently causing PDC to be altered. This review further summarizes evidence for the metabolism mechanism of the heart under normal and pathological conditions including ischemia, diabetes, hypertrophy and heart failure.

Keywords

Glucose metabolism; Heart disease; Pyruvate Dehydrogenase Complex.

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