2. Academic Validation
  3. Amphirionin-2, a novel linear polyketide with potent cytotoxic activity from a marine dinoflagellate Amphidinium species

Amphirionin-2, a novel linear polyketide with potent cytotoxic activity from a marine dinoflagellate Amphidinium species

  • Bioorg Med Chem Lett. 2015 Feb 1;25(3):635-8. doi: 10.1016/j.bmcl.2014.12.003.
Keiko Kumagai 1,  Mika Minamida 2,  Mai Akakabe 1,  Masayuki Tsuda 1,  Yuko Konishi 1,  Akira Tominaga 3,  Masashi Tsuda 4,  Eri Fukushi 5,  Jun Kawabata 5
Affiliations

Affiliations

  • 1 Science Research Center, Kochi University, Kochi 783-8505, Japan.
  • 2 Department of Applied Science, Kochi University, Kochi 783-8502, Japan.
  • 3 Graduate School of Kuroshio Science and Kochi Medical School, Kochi University, Kochi 783-8505, Japan.
  • 4 Center for Advanced Marine Core Research, Kochi University, Kochi 783-8502, Japan. Electronic address: mtsuda@kochi-u.ac.jp.
  • 5 Research Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido 060-8589, Japan.
PMID: 25534608 DOI: 10.1016/j.bmcl.2014.12.003
Abstract

A novel linear polyketide, amphirionin-2 (1), with two unique hexahydrofuro[3,2-b]furan moieties has been isolated from the cultivated algal cells of a benthic dinoflagellate Amphidinium sp. (strain KCA09051). The structure was elucidated on the basis of detailed analyses of 2D NMR data, and the absolute configuration of C-5 was determined by using modified Mosher's method. Amphirionin-2 (1) exhibited potent cytotoxic activity against human colon carcinoma Caco-2 cells and human lung adenocarcinoma A549 cells.

Keywords

Amphidinium; Cytotoxic activity; Dinoflagellate; Hexahydrofuro[32-b]furan; Polyketide.

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