2. Academic Validation
  3. Sesquiterpenoid tropolone glycosides from Liriosma ovata

Sesquiterpenoid tropolone glycosides from Liriosma ovata

  • J Nat Prod. 2015 Feb 27;78(2):315-9. doi: 10.1021/np5006696.
Jun Ma 1,  Rahul S Pawar,  Erich Grundel,  Eugene P Mazzola,  Clark D Ridge,  Takashi Masaoka,  Stuart F J Le Grice,  Jennifer Wilson,  John A Beutler,  Alexander J Krynitsky
Affiliations

Affiliation

  • 1 Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration , 5100 Paint Branch Parkway, College Park, Maryland 20740, United States.
PMID: 25587934 DOI: 10.1021/np5006696
Abstract

Two new sesquiterpenoid tropolone glycosides, liriosmasides A (1) and B (2), along with two known compounds, secoxyloganin and oplopanpheside C, were isolated from a methanol extract of the roots of Liriosma ovata. The structures of 1 and 2 were elucidated by spectroscopic methods including 1D and 2D NMR and by high-resolution mass spectrometry involving an ultra-high-performance liquid chromatography-quadrupole-orbital ion trap mass spectrometric (UHPLC-Q-Orbitrap MS) method. Compound 1 showed weak inhibitory activity against HIV RNase H.

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