2. Academic Validation
  3. Penicitols A-C and penixanacid A from the mangrove-derived Penicillium chrysogenum HDN11-24

Penicitols A-C and penixanacid A from the mangrove-derived Penicillium chrysogenum HDN11-24

  • J Nat Prod. 2015 Feb 27;78(2):306-10. doi: 10.1021/np500586r.
Wenqiang Guo 1,  Dan Li,  Jixing Peng,  Tianjiao Zhu,  Qianqun Gu,  Dehai Li
Affiliations

Affiliation

  • 1 Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
PMID: 25611519 DOI: 10.1021/np500586r
Abstract

Three new citrinin analogues, penicitols A-C (1-3), and one new xanthone derivative, penixanacid A (4), together with four known biogenetically related compounds (5-8), were discovered from the extract of a mangrove-derived fungus, Penicillium chrysogenum HND11-24. The structures of penicitols A-C and penixanacid A were established through analysis of extensive spectroscopic data. Their cytotoxic activity against HeLa, BEL-7402, HEK-293, HCT-116, and A549 cell lines was evaluated.

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