2. Academic Validation
  3. Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae)

Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae)

  • Eur J Med Chem. 2015 Mar 26:93:93-100. doi: 10.1016/j.ejmech.2015.01.012.
Linh H Mai 1,  Guy G Chabot 2,  Philippe Grellier 3,  Lionel Quentin 2,  Vincent Dumontet 4,  Cyril Poulain 4,  Laila S Espindola 5,  Sylvie Michel 1,  Hue T B Vo 6,  Brigitte Deguin 1,  Raphaël Grougnet 7
Affiliations

Affiliations

  • 1 Laboratoire de Pharmacognosie, UMR/CNRS 8638, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4, Avenue de l'Observatoire, 75006 Paris, France.
  • 2 Laboratoire de Pharmacologie Chimique, Génétique et Imagerie U1022 Inserm-UMR8151 CNRS, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4, Avenue de l'Observatoire, 75006 Paris, France.
  • 3 Muséum National d'Histoire Naturelle, UMR 7245 CNRS, Molécules de Communication et Adaptation des Micro-organismes, 61 rue Buffon, F-75231 Paris Cedex 05, France.
  • 4 Centre de recherche de Gif, Institut de Chimie des Substances Naturelles, UPR2301 CNRS, Avenue de la Terrasse, Gif-sur-Yvette Cedex, France.
  • 5 Laboratorio de Farmacognosia, Universidade de Brasilia, Campus Universitario Darcy Ribeiro, Asa Norte, 70910-900 Brasilia, DF, Brazil.
  • 6 Faculty of Pharmacy, Ho Chi Minh University of Medicine and Pharmacy, 41 Dinh Tien Hoang St., District 1, Ho Chi Minh City, Viet Nam.
  • 7 Laboratoire de Pharmacognosie, UMR/CNRS 8638, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4, Avenue de l'Observatoire, 75006 Paris, France. Electronic address: raphael.grougnet@parisdescartes.fr.
PMID: 25659770 DOI: 10.1016/j.ejmech.2015.01.012
Abstract

A series of 16 Flavonoids were isolated and prepared from bud exudate of Gardenia urvillei and Gardenia oudiepe, endemic to New Caledonia. Most of them are rare polymethoxylated Flavones. Some of these compounds showed noticeable activity against Leishmania (Leishmania) amazonensis, Plasmodium falciparum and Trypanosoma brucei gambiense, in addition to tubulin polymerization inhibition at low micromolar concentration. We also provide a full set of NMR data as some of the Flavones were incompletely described.

Keywords

Antileishmanial; Antiplasmodial; Antivascular agents; Endothelial cells; Flavonoids; Trypanocidal.

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