2. Academic Validation
  3. Salternamides A-D from a Halophilic Streptomyces sp. Actinobacterium

Salternamides A-D from a Halophilic Streptomyces sp. Actinobacterium

  • J Nat Prod. 2015 Apr 24;78(4):836-43. doi: 10.1021/acs.jnatprod.5b00002.
Seong-Hwan Kim 1,  Yoonho Shin 1,  So-Hyoung Lee 2,  Ki-Bong Oh 2,  Sang Kook Lee 1,  Jongheon Shin 1,  Dong-Chan Oh 1
Affiliations

Affiliations

  • 1 †Natural Products Research Institute, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
  • 2 ‡Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-921, Republic of Korea.
PMID: 25700232 DOI: 10.1021/acs.jnatprod.5b00002
Abstract

Salternamides A-D (1-4), the first secondary metabolites discovered from saltern-derived actinomycetes, were isolated from a halophilic Streptomyces strain isolated from a saltern on Shinui Island in the Republic of Korea. The planar structures of the salternamides, which are new members of the manumycin family, were elucidated by a combination of spectroscopic analyses. The absolute configurations of the salternamides were determined by chemical and spectroscopic methods, including the modified Mosher's method, J-based configuration analysis, and circular dichroism spectroscopy. Salternamide A (1), which is the first chlorinated compound in the manumycin family, exhibited potent cytotoxicity against a human colon Cancer cell line (HCT116) and a gastric Cancer cell line (SNU638) with submicromolar IC50 values. Salternamides A and D were also determined to be weak Na(+)/K(+) ATPase inhibitors.

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