2. Academic Validation
  3. Lumazine peptides from the marine-derived fungus Aspergillus terreus

Lumazine peptides from the marine-derived fungus Aspergillus terreus

  • Mar Drugs. 2015 Mar 12;13(3):1290-303. doi: 10.3390/md13031290.
Minjung You 1,  Lijuan Liao 2,  Soo Hyun Hong 3,  Wanki Park 4,  Dah In Kwon 5,  Jeeyeon Lee 6,  Minsoo Noh 7,  Dong-Chan Oh 8,  Ki-Bong Oh 9,  Jongheon Shin 10
Affiliations

Affiliations

  • 1 Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. lovemin90@snu.ac.kr.
  • 2 Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. lxycxf@snu.ac.kr.
  • 3 Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. hong-soo-hyun@hanmail.net.
  • 4 Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea. adamas2001@hanmail.net.
  • 5 College of Pharmacy, Seoul National University, Seoul 151-742, Korea. dahin@snu.ac.kr.
  • 6 College of Pharmacy, Seoul National University, Seoul 151-742, Korea. jyleeut@snu.ac.kr.
  • 7 Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. minsoonoh@snu.ac.kr.
  • 8 Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. dongchanoh@snu.ac.kr.
  • 9 Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea. ohkibong@snu.ac.kr.
  • 10 Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. shinj@snu.ac.kr.
PMID: 25775424 DOI: 10.3390/md13031290
Abstract

Terrelumamides A (1) and B (2), two new lumazine-containing Peptides, were isolated from the culture broth of the marine-derived fungus Aspergillus terreus. From the results of combined spectroscopic and chemical analyses, the structures of these compounds were determined to be linear assemblies of 1-methyllumazine-6-carboxylic acid, an amino acid residue and anthranilic acid methyl ester connected by peptide bonds. These new compounds exhibited pharmacological activity by improving Insulin sensitivity, which was evaluated in an adipogenesis model using human bone marrow mesenchymal stem cells. In addition, the compounds exhibited fluorescence changes upon binding to DNA, demonstrating their potential applications to DNA sequence recognition.

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