Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors

Bioorg Med Chem Lett. 2015 Apr 15;25(8):1742-1746. doi: 10.1016/j.bmcl.2015.02.074.

Lidia A Baltina ¹, Vladimir V Zarubaev ², Lia A Baltina ³, Iana A Orshanskaya ², Alina I Fairushina ³, Oleg I Kiselev ², Marat S Yunusov ³

Affiliations

1 Institute of Organic Chemistry Ufa Research Centre of Russian Academy of Sciences, 71, prospect Oktyabrya, Ufa 450054, Russian Federation. Electronic address: baltina@anrb.ru.
2 Influenza Research Institute, Ministry of Health of Russia, 15/17, prof. Popov str., St. Peterburg 197376, Russian Federation.
3 Institute of Organic Chemistry Ufa Research Centre of Russian Academy of Sciences, 71, prospect Oktyabrya, Ufa 450054, Russian Federation.

PMID: 25801933 DOI: 10.1016/j.bmcl.2015.02.074

Abstract

This Letter describes the synthesis and Antiviral activity study of some glycyrrhizic acid (GL) derivatives against influenza A/H1N1/pdm09 virus in MDCK cells. Conjugation of GL with l-amino acids or their methyl esters, and amino sugar (d-galactose amine) dramatically changed its activity. The most active compounds were GL conjugates with aromatic Amino acids methyl esters (phenylalanine and tyrosine) (SI=61 and 38), and S-benzyl-cysteine (SI=71). Thus modification of GL is a perspective route in the search of new antivirals, and some of GL derivatives are potent as anti-influenza A/H1N1 agents.

Keywords

Analogs; Antivirals; Derivatives; Glycyrrhizic acid; Influenza A/H1N1 virus.

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