2. Academic Validation
  3. Dactylomelane diterpenes from the sea hare Aplysia depilans

Dactylomelane diterpenes from the sea hare Aplysia depilans

  • J Nat Prod. 2015 Mar 27;78(3):462-7. doi: 10.1021/np500851w.
Anastasia Petraki 1,  Efstathia Ioannou 1,  Panagiota Papazafiri 2,  Vassilios Roussis 1
Affiliations

Affiliations

  • 1 †Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
  • 2 ‡Department of Animal and Human Physiology, Faculty of Biology, School of Science, University of Athens, Panepistimiopolis Zografou, Athens 15784, Greece.
PMID: 25814031 DOI: 10.1021/np500851w
Abstract

A chemical investigation of the organic extract of the sea hare Aplysia depilans, collected off Skyros Island, Greece, yielded eight new brominated diterpenes (1-8), featuring the rare dactylomelane skeleton, together with the previously reported luzodiol (9). The structure elucidation and the assignment of the relative configurations of the new Natural Products were based on extensive NMR spectroscopic and MS spectrometric analyses. Compounds 1-9 were evaluated for their cytotoxic activities against five human tumor cell lines, but were proven inactive.

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