Cytochalasin derivatives from a jellyfish-derived fungus Phoma sp

Bioorg Med Chem Lett. 2015;25(10):2096-9. doi: 10.1016/j.bmcl.2015.03.080.

Eun La Kim ¹, Haibo Wang ¹, Ju Hee Park ¹, Jongki Hong ², Jae Sue Choi ³, Dong Soon Im ¹, Hae Young Chung ¹, Jee H Jung ⁴

Affiliations

1 College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
2 College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
3 Department of Food Science and Nutrition, Pukyong National University, Busan 608-737, Republic of Korea.
4 College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. Electronic address: jhjung@pusan.ac.kr.

PMID: 25881821 DOI: 10.1016/j.bmcl.2015.03.080

Abstract

Four new cytochalasin derivatives (1-4), together with proxiphomin (5), were isolated from a jellyfish-derived fungus Phoma sp. The planar structures and relative stereochemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed moderate cytotoxicity against a small panel of human solid tumor cell lines (A549, KB, and HCT116).

Keywords

Cytochalasin; Cytotoxicity; Jellyfish-derived fungus; Nemopilema nomurai; Phoma sp..

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